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Goldfrank's Toxicologic Emergencies, 11th Edition

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Lewis S. Nelson, Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank, and Silas W. Smith

Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins.

Fully referenced and supported by a cohesive organization and full-color format, Goldfrank's begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations.
The Eleventh Edition of Goldfrank's Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis.
New to this edition:
  • Additional cases and "Special Considerations" chapters designed to enhance clinical decision-making and patient outcomes
  • New "Antidotes in Depth" provides timely, critical information on toxicologic treatment strategies
  • New content on toxicogenomics explores its increasingly important role in predictive toxicology
  • Chapter-ending bulleted summaries of key points
  • Updated coverage of synthetics such as "K2"
  • Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools
Table of Contents
1. Historical Principles and Perspectives
Paul M. Wax
2. Toxicologic Misfortunes and Catastrophes in History
Paul M. Wax



3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman
4. Principles of Managing the Acutely Poisoned or Overdosed Patient
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions]SC1. Principles of Antidote Stocking
5. Decontamination Principles: Prevention of Gastrointestinal Absorption
Lotte C. G. Hoegberg and Anne-Bolette Gude
SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption
A1. Activated Charcoal
Silas W. Smith and Mary Ann Howland
A2. Whole-Bowel Irrigation and Other Intestinal Evacuants
Silas W. Smith and Mary Ann Howland
6. Principles and Techniques Applied to Enhance Elimination
David S. Goldfarb and Marc Ghannoum
7. Laboratory Principles
Petrie M. Rainey
8. Principles of Diagnostic Imaging
David T. Schwartz
9. Pharmacokinetic and Toxicokinetic Principles
Mary Ann Howland




10. Chemical Principles
Stephen J. Traub and Lewis S. Nelson
11. Biochemical and Metabolic Principles
Kurt C. Kleinschmidt and Kathleen A. Delaney
12. Fluid, Electrolyte, and Acid-Base Principles
Alan N. Charney and Robert S. Hoffman
13. Neurotransmitters and Neuromodulators
Steven C. Curry, Ayrn D. O'Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik
14. Withdrawal Principles
Richard J. Hamilton


15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles
Cathleen Clancy
16. Cardiologic Principles II: Hemodynamics
Robert A. Hessler
17. Dermatologic Principles
Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson
SC3. Transdermal Toxicology
Lewis S. Nelson 18. Gastrointestinal Principles
Matthew D. Zuckerman and Richard J. Church
19. Genitourinary Principles
Jason Chu
20. Hematologic Principles
Marco L.A. Sivilotti
21. Hepatic Principles
Kathleen A. Delaney
22. Neurologic Principles
Rama B. Rao
23. Oncologic Principles
Richard Wang
24. Ophthalmic Principles
Adhi Sharma
25. Otolaryngologic Principles
William Chiang
26. Psychiatric Principles
Erin A. Zerbo and Andrea M. Kondracke
Publication Date March 2019
Format Hardcover, 2096 pages
Product Code 32017